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Some advanced protocols split the daily dose into two administrations, morning and evening

A Cochrane review comparing oral and intramuscular B12 found comparable effects on blood levels, and the same principle of good absorption applies to the subcutaneous route

It is an unapproved investigational compound that did not complete clinical development, has not been authorized by Health Canada for any human or veterinary indication, and is not intended to diagnose, treat, cure, or prevent any disease

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About B12 LIPO What Are B-12 Injections

Fatal hypokalemia may occur when severe megaloblastic anemia is treated intensively with vitamin B12, as a result of increased erythrocyte potassium requirements